Ash and friends arrive at a Pokemon Center late in the night and Nurse Joy is nowhere to be seen, only an extremely clumsy Blissey that provides Ash more pain then hospitality. Meanwhile, Team Rocket break into the center to find some food, and are shocked when they find out the Blissey is the same one that Jessie went to nursing school with many years ago. Now Jessie is torn between her evil deeds with Team Rocket and her friendship with Blissey.